Master the mathematics and mechanisms behind every drug decision
From Michaelis-Menten kinetics and enzyme inhibition to multi-compartment PK models and rational dosing regimens — this is the quantitative pharmacology course that turns abstract equations into clinical precision.
If you can derive it, you will never need to memorise it — and that is the standard I hold this course to.— Dr. J Raymond ABK
What you'll learn
What you'll be able to do
- Derive and apply the Michaelis-Menten equation to calculate Km, Vmax, and enzyme reaction rates in drug metabolism scenarios
- Distinguish between competitive, non-competitive, and irreversible enzyme inhibition and predict their effects on pharmacological action
- Interpret and construct full dose-response curves, identifying EC50, Emax, potency, and efficacy for any drug class
- Apply first-order and zero-order kinetics to calculate drug half-life, clearance, and volume of distribution
- Build and solve multi-compartment pharmacokinetic models to predict drug concentration-time profiles
- Design rational dosing regimens by integrating bioavailability, elimination rate constants, and therapeutic window data
How it works
A school that adapts to you
This isn't a set of static videos. Every lesson is generated live and tuned to where you actually are.
We learn your level
A quick placement check tailors your starting point so you're never bored or lost.
Lessons adapt as you go
Each lesson is written for your pace and your goal, adjusting as your skills grow.
Your AI coach keeps you moving
Checkpoints, feedback, and gentle nudges turn progress into a real result.
The curriculum
What's inside your school
6 modules · 25 lessons
Foundations of Drug-Enzyme Interactions
Establishes the biochemical and kinetic principles governing how drugs interact with enzymes, culminating in full command of the Michaelis-Menten framework.
- 1.1Enzymes as Drug Targets: Structure and Catalytic PrinciplesIncluded
- 1.2The Michaelis-Menten Equation: Derivation and MeaningIncluded
- 1.3Calculating Km and Vmax: Lineweaver-Burk and Modern MethodsIncluded
- 1.4Enzyme Kinetics in Drug Metabolism ScenariosIncluded
Enzyme Inhibition and Pharmacological Consequences
Covers the mechanisms, kinetic signatures, and clinical implications of all major classes of enzyme inhibition.
- 2.1Competitive Inhibition: Kinetics and Clinical ExamplesIncluded
- 2.2Non-Competitive and Uncompetitive InhibitionIncluded
- 2.3Irreversible and Mechanism-Based InhibitionIncluded
- 2.4Predicting Drug Interactions from Inhibition ProfilesIncluded
Dose-Response Relationships
Builds quantitative and conceptual mastery of dose-response curves, linking drug concentration to pharmacological effect.
- 3.1Graded Dose-Response Curves: EC50, Emax, and the Hill EquationIncluded
- 3.2Potency vs. Efficacy: Definitions, Differences, and Clinical RelevanceIncluded
- 3.3Partial Agonists, Antagonists, and Shifts in Dose-Response CurvesIncluded
- 3.4Quantal Dose-Response, Therapeutic Index, and Safety MarginsIncluded
Drug Elimination and Clearance
Quantifies how drugs are removed from the body using first-order and zero-order kinetic models and key clearance parameters.
- 4.1First-Order Elimination: Half-Life, Rate Constants, and Exponential DecayIncluded
- 4.2Zero-Order Kinetics and Capacity-Limited EliminationIncluded
- 4.3Hepatic and Renal Clearance: Mechanisms and CalculationsIncluded
- 4.4Volume of Distribution: Concept, Calculation, and Clinical InterpretationIncluded
Pharmacokinetic Modelling
Develops the ability to build, solve, and interpret one- and multi-compartment PK models to predict drug concentration-time profiles.
- 5.1One-Compartment Model: IV Bolus and Oral AdministrationIncluded
- 5.2Bioavailability and First-Pass MetabolismIncluded
- 5.3Two-Compartment and Multi-Compartment ModelsIncluded
- 5.4Non-Compartmental Analysis: AUC, AUMC, and Mean Residence TimeIncluded
Rational Dosing Regimen Design
Integrates all prior PK/PD principles to design, optimise, and adjust dosing regimens for safe and effective clinical use.
- 6.1Loading Doses and Maintenance Doses: Derivation and ApplicationIncluded
- 6.2Steady-State Concepts and Accumulation with Multiple DosingIncluded
- 6.3Therapeutic Drug Monitoring and Dose IndividualisationIncluded
- 6.4Dose Adjustments in Renal and Hepatic ImpairmentIncluded
- 6.5Integrating PK/PD for Evidence-Based Dosing DecisionsIncluded
Who it's for
Is this you?
Medical students
Building the quantitative pharmacology foundation needed to ace pharmacology exams and reason confidently through drug dosing in clinical rotations.
Pharmacy students
Going beyond drug lists to master the kinetic and mechanistic principles — enzyme inhibition, clearance, dosing regimens — that underpin every dispensing and counselling decision.
Biomedical science undergraduates
Seeking the rigorous, equation-level grounding in pharmacokinetics and drug-enzyme interactions required for advanced study, dissertations, or graduate research.
Early-career clinicians
Filling in the quantitative gaps left by clinical training — from PK/PD integration to dose adjustment in organ impairment — to make sharper, evidence-based prescribing decisions.
Pharmacology researchers
Strengthening their command of compartmental modelling, non-compartmental analysis, and dose-response methodology to engage critically with primary literature and experimental data.
Licensing exam candidates
Preparing for medical or pharmacy board assessments by mastering the worked problem-solving skills — half-life calculations, inhibition kinetics, therapeutic index — that are directly examined.
Questions
Frequently asked
Your teacher
A note from your teacher
Dr. J Raymond ABK
If you have ever sat in a pharmacology lecture and felt the gap between the equation on the board and any real understanding of what it means — you are exactly who this course is for.
I have worked with medical students, pharmacy students, and early-career researchers who are bright, motivated, and working hard, yet still feel like pharmacokinetics and enzyme kinetics are subjects they are somehow getting through rather than genuinely mastering. That feeling is not a reflection of your ability. It is almost always a reflection of how the material was taught — rushed through, presented as a collection of formulas to apply rather than principles to understand, and disconnected from the clinical decisions that give it meaning.
This course is built on a different premise: that if you understand where the Michaelis-Menten equation comes from, you will never need to memorise it. That if you can see exactly why competitive inhibition raises the apparent Km without changing Vmax, the clinical implications for drug interaction follow logically rather than by rote. That if you build a pharmacokinetic model from its underlying assumptions, you can interrogate its outputs critically — rather than treating a concentration-time curve as a black box.
Every section of this curriculum is structured around that principle: derive first, then apply. We work through equations step-by-step, with every variable accounted for. We anchor mechanisms in clinical examples — real drug classes, real dosing problems, real consequences of getting the pharmacology right or wrong. And we move systematically from drug-enzyme interactions through dose-response relationships, elimination kinetics, compartmental modelling, and all the way to the design of rational dosing regimens that integrate everything you have learned.
By the end of this course, you will be able to sit down with a drug's pharmacokinetic data sheet and do something useful with it. You will be able to reason through an enzyme inhibition profile and predict what it means for a patient on polypharmacy. You will be able to design a loading and maintenance dose regimen from first principles, and adjust it for renal or hepatic impairment with confidence rather than guesswork.
That is the level of command this course is designed to give you. If you are ready to stop memorising and start understanding, I am glad you are here.
— Dr. J Raymond ABK
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- 6 modules, 25 lessons
- AI-adaptive lessons tuned to your level
- Quizzes & checkpoints to lock in progress
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